Loss of mental focus, memory, dizziness, headache, tinnitus, vertigo, anxiety, stress, seasonal affective disorder, nervous tension, hypertension, restorative for anaemia and anorexia, peripheral arterial deficiency (as it tones and strengthens blood vessels), and cerebral arteriosclerosis. Therefore, it is also helpful for post-stroke victims.

It is an energetically cooling plant useful to treat heating conditions and inflammation. It is the indole alkaloids present in lesser periwinkle that are of most interest. It is cited as a cerebral tonic by Matthew Wood (1), and with its vasodilatory and stimulating effects it improves blood flow to the brain and is recommended in cerebral atherosclerosis (plaquing of the arteries) and also said to reduce high blood pressure (2).

With an increasing prevalence of Alzheimer’s, the ability of V. minor to promote cerebral circulation in addition to its potential to ameliorate atherosclerosis makes the herb a good candidate for use for current neurodegenerative challenges.

Periwinkle was understood for its astringent nature in as early as 40–90 AD by the Greek physician Dioscorides who noted in his De Materia Medica that “the leaves be drunk in wine to lessen excessive discharges of the bowels……and cure the pain of the matrix (womb)” (3).

Pliny (23–79 AD) recommended periwinkle for bleeding, diarrhoea, to heal wounds, and as an antidote to poisonous bites when taken with wine. It was even believed to prevent miscarriage when fastened around the thigh of a pregnant woman (McIntyre, 2022) (3). 

Apuleius, 5th century, wrote in his herbarium: “This wort is of good advantage….against devil sickness and demoniacal possessions…against snakes and wilde beasts and against poisons….and for envy and terror….that thou may have grace. If thou hast the wort with thee…..prosperous and ever acceptable.” (4).

In the 13th century, Boke of Secrets it was said “Perwynke induceth love between man and wife if…used in their meales,” (4).

Herbalist John Gerard famously said of its virtues that if “the leaves stamped, and the juice given to drink in red wine, stoppeth the…… spitting of blood and it likewise stoppeth the inordinate course of the monthly sickness (heavy menses).”  (5)

One of the most famous herbalists, Nicholas Culpeper, said it could be used it as an aphrodisiac when shared amongst lovers, and that it stopped the bleeding of the mouth and nose and was also good for the nightmares (4,6).

Periwinkle tea was thought of as a good remedy for scurvy, to relax sore throats and inflamed tonsils and to gargle with (4).

Bruised leaves inserted into nostrils were used to stop bleeding, and when used as an ointment with lard for its healing and anti-inflammatory properties, periwinkle was a useful remedy for skin complaints and for bleeding piles. The flowers of Vinca minor are thought of as gently purgative when made into a syrup, and considered a gentle laxative for children (4).

V. minor has a particular affinity to the head and is viewed as a relaxing circulatory stimulant, which helps to clear restriction and promote the free flow of materials. Consequently, oxygen uptake is enhanced and cerebral performance is improved. 

Useful in head issues like headaches, indicated for eye disease, ear problems like tinnitus, vertigo and labrynthitis and thought of as helpful in lowering high blood pressure and useful in Alzheimer’s. A synthetic version of an alkaloid from vinca called vinpocetine has been shown in studies to be usefeul for treatment for cognitive impairment and neurodegeneration (22). 

Some herbalists substitute for Gingko and think of it as a peripheral vasodilator that improves oxygen and nutrient flow to the brain. Therefore it could be used for post-stroke victims to enhance the blood flow to that area. However, interestingly many modern clinical herbalists do not use vinca any more despite there being plenty of recorded use in earlier literature.

Almost no studies have been done on whole plant extracts of Vinca minor, whereas numerous studies have been done using the isolated compound, the indole alkaloid, vincamine.

Vincamine, a vinca alkaloid found in the leaves of Vinca minor is the strongest represented constituent and represents about 20–25% of all of the 40 or so alkaloids found so far. Specifically, vincamine is a monoterpene indole alkaloid with vasodilatory properties and studies indicate that it increases the regional cerebral blood flow. It is listed here as an antihypertensive, antineoplastic and peripheral vasodilator and vasodilator (5).

Vincamine has peripheral circulatory benefits and is used as a cerebral stimulant and vasodilator due to its ability to pass through the blood brain barrier and modulate brain circulation and neuronal homeostasis (6,7).

The monoterpene indole alkaloids from Vinca minor have identified a new structural scaffold for treatment of Alzheimer’s disease. There were a number of indole alkaloids that showed both the ability of blood-brain barrier penetration and remarkable hBuChE, and POP inhibition potency (both suggested markers in Alzheimers disease progression) (8).

In a study on the therapeutic efficacy of vincamine in dementia, Fischhof et al. showed in a double-blind placebo-controlled trial of 142 patients between the ages of 50–85 years who had either degenerative dementia of the Alzheimer’s type or multi-infarct dementia. After a 12-week time period the controlled group who were given 30mg vincamine twice daily performed significantly better in all four target variables compared to the placebo group (9).

There was a study done recently by Hasa that showed a sevenfold improvement in oral bioavailability of vincamine when administered to rats as part of a whole plant compared to the pure chemical compound (2013) (10), something we know as the ‘entourage effect’, which is a major premise of herbalism as we use phytochemically diverse extracts. 

There are actually two very similar plants with different uses: lesser periwinkle and greater periwinkle. Unlike lesser periwinkle, described above, greater periwinkle (larger leaves) is now known to have an affinity for the reproductive and lower digestive systems, due to its strong astringency and blood staunching actions. It is especially useful to stem heavy menstrual bleeding or to reduce bleeding ulcers in the digestive system.

Lesser periwinkle was known as The Sorcerer’s Violet or Devils Eye, and it was considered a favourite flower of the“wise folk (witches) for making charms and love potions. It was even said to be able to exorcise evil spirits (11). It was also said that even staring into the beautiful flower alone could bring back memories.

Periwinkle was considered the Female Patron Herb of Wiccans she was guided by the planet Venus (13).

Thought to be endemic to Spain initially it then over time found its way to our more northernly shores. Its invasive nature gave it an advantage on disturbed ground and, hence, it was often found in graveyards which is thought to have bound its association with death (21). V. minor has a ground trailing habit (4) . A bonus is that members of this genus are rarely troubled by browsing deer or rabbits. It spreads rapidly by long trailing and rooting stems once it is established and will swamp out smaller plants (13). Given the chance, it will climb up though other plants that it uses for support as seen here situated on the roadside.

Habitat loss and over-harvesting from the wild are two of the biggest threats faced by medicinal plant species. There are an increasing number of well-known herbal medicines at risk of extinction. We must therefore ensure that we source our medicines with sustainability in mind. 

The herb supplement industry is growing at a rapid rate and until recent years a vast majority of medicinal plant produce in global trade was of unknown origin. There are some very real and urgent issues surrounding sustainability in the herb industry. These include environmental factors that affect the medicinal viability of herbs, the safety of the habitats that they are taken from, as well as the welfare of workers in the trade.

The botanical supply chain efforts for improved visibility (transparency and traceability) into verifiably sustainable production sites around the world is now certificated through the emergence of credible international voluntary sustainability standards (VSS).

Read our article on Herbal quality and safety: What to know before you buy and Sustainable sourcing of herbs to learn more about what to look for and questions to ask suppliers about sustainability.

Herbal Medicines are often extremely safe to take, however it is important to buy herbal medicines from a reputed supplier. Sometimes herbs bought from unreputable sources are contaminated, adulterated or substituted with incorrect plant matter.

Some important markers for quality to look for would be to look for certified organic labelling, ensuring that the correct scientific/botanical name is used and that suppliers can provide information about the source of ingredients used in the product.

A supplier should be able to tell you where the herbs have come from. There is more space for contamination and adulteration when the supply chain is unknown.

Plant established seedlings or small pot plants into their permanent positions in late spring or early summer, after the last expected frosts. Water regularly. A very easily grown plant, it succeeds in almost any soil but prefers those that are on the richer side. It grows well in heavy clay soils. Plants are very shade tolerant but they do not flower so well in deep shade. It can grow well under deciduous trees, and in such a position it can succeed in dry soils. Established plants are drought tolerant (13).

Only old anecdotal recipes like using the flowers in a syrup as a gentle laxative. See our article on how to make herbal syrups to learn how to make this.

1. McIntyre, A, 2019. The Complete Herbal Tutor. Aeon Books. London, UK.
2. Wood, M. 2008. The Earthwise Herbal Volume 1: A complete guide to old world medicinal plants. North Atlantic Books. Berkeley, California, U.S.A.
3. McIntyre, A, 2002. The Complete Floral Healer. Sterling Publishing. New York, U.S.A.
4. Culpepper, N. 1814. The Complete Herbal. Accessed: https://archive.org/details/ cu31924001353279/page/n119/mode/2up Publisher: Richard Evans, Spitalfields, London.
5. Gerard, J. 1597. The General History if Plants. Available at: https://www.exclassics.com/herbal/ herbalv3.pdf (Accessed: 11.07.2022). 
6. Grieve, M, 1931. A Modern Herbal Vol II. Stone Basin Books, USA.
   Grieve, M. 1931. A Modern Herbal. Available at: https://www.botanical.com/botanical/mgmh/p/
7. Drugbank Online. 2022. Vincamine. Available at: https://go.drugbank.com/drugs/DB13374 (Accessed 18.01.2022).
8. Hong,Y., & Yu-Hong, S. 2011. Vincamine-producing endophytic fungus isolated from Vinca minor. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0944711311000067 (Accessed: 04.04.2022).
9.  Vrabek, R. et al. 2021. Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer’s disease. Available at: https:// www.sciencedirect.com/science/article/pii/S0031942221003666 (Accessed: 05.04.2022).
10. P. et al. 1996. Therapeutic Efficacy of Vincamine in Dementia. Available at: https:// www.karger.com/Article/Abstract/119288 (Accessed 18.01.2022).
11. Hasa, D. et al. 2013. Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine’s oral bioavailability enhancer. Available at: https://pubmed.ncbi.nlm.nih.gov/23238273/ (Accessed: 11.07.2022).
12. White Rabbit Institute of Healing. 2022. Periwinkle. Available at: https:// www.whiterabbitinstituteofhealing.com/herbs/periwinkle/ (Accessed: 05.04.2022).
13. Witches Garden. Available at: http://www.earthwitchery.com/periwinkle.html (Accessed: 05.04.22)
14. Pengelly, A. 2004. The Constituents of Medicinal Plants. CABI, Boston, USA.
15. McIntyre, A. Boudin, M. 2012. Dispensing with Tradition. McIntyre & Boudin, Cheltenham, UK.
16. Vinca minor Interactions. NatMed Pro – Login. 2024. Accessed May 8, 2024. https://naturalmedicines.therapeuticresearch.com/tools/interaction-checker.aspx#.
17. Holmes, P. 2007. The Energetics of Western Medicine. Fourth Edition. Beacon Press, Boston, USA.
18. Vinca minor Monograph. NatMed Pro – Login. Accessed May 8, 2024. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=476.
19. McIntyre, A. 2022. Healing With Flowers. Aeon Books, London, UK.
20. Chevallier, A. 2016. Encyclopaedia of Herbal Medicine. Dorling Kindersley, London, UK.
21. Bogan, Claire, 2020. Periwinkle. Available at: http://www.feritradition.org/grimoire/garden/ periwinkle.html (Accessed: 17.01.2022).
22. Szatmári S, Whitehouse P. Vinpocetine for cognitive impairment and dementia. Cochrane Library. 2003;2010(1). doi:10.1002/14651858.cd003119